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Neuronal nitric oxide synthase is necessary for elimination of Giardia lamblia infections in mice. Dual functional monoclonal antibody PF targets integrin alpha5beta1 and elicits potent antibody-dependent cellular cytotoxicity. Pancreatic duodenal homeobox 1 protein is a novel beta-cell-specific autoantigen for type I diabetes. Lab Invest 90 1: Distinct patterns of Fas cell surface expression during development of T- or B-lymphocyte lineages in normal, scid, and mutant mice lacking or overexpressing p53, bcl-2, or rag-2 genes.

Cell Growth Differ 7 1: Mol Cancer Res 10 4: PTEN deletion and heme oxygenase-1 overexpression cooperate in prostate cancer progression and are associated with adverse clinical outcome. Mol Cell Biol 18 6: Clinicopathological correlations and therapeutical implications.

Int J Cancer 6: Mutations that affect meiosis in male mice influence the dynamics of the mid-preleptotene and bouquet stages. Retention of human bone marrow-derived cells in murine lungs following bleomycin-induced lung injury. Interaction of natural killer cells with Trypanosoma cruzi-infected fibroblasts. The pdelta isoform of phosphatidylinositol 3-kinase controls susceptibility to Leishmania major by regulating expansion and tissue homing of regulatory T cells.

Nat Med 20 3: Cardiac mass and cardiomyocyte size are governed by different genetic loci on either autosomes or chromosome Y in recombinant inbred mice. Physiol Genomics 31 2: Cardiac apoptosis in severe relapsing fever borreliosis. ALK mutants in the kinase domain exhibit altered kinase activity and differential sensitivity to small molecule ALK inhibitors. Interleukin-7 regulates adipose tissue mass and insulin sensitivity in high-fat diet-fed mice through lymphocyte-dependent and independent mechanisms.

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PLoS One 7 6: Bmi-1 is a crucial regulator of prostate stem cell self-renewal and malignant transformation. Cell Stem Cell 7 6: Memo is a copper-dependent redox protein with an essential role in migration and metastasis. Acute graft rejection of human fetal pancreas allografts using donor-specific human peripheral blood lymphocytes in the SCID mouse.

Split tolerance between spleen and lymph node cells in severe combined immunodeficiency mice grafted with AKR fetal liver cells. Int Immunol 6 8: Differential susceptibility of inbred mouse strains to dextran sulfate sodium-induced colitis. Am J Physiol 3 Pt 1: Stem Cells 34 9: Positive and negative selection in transgenic mice expressing a T-cell receptor specific for influenza nucleoprotein and endogenous superantigen. Dev Immunol 3 3: Idd loci synergize to prolong islet allograft survival induced by costimulation blockade in NOD mice.

Matrix metalloproteinase 9 MMP-9 is upregulated during scarless wound healing in athymic nude mice. Matrix Biol 25 8: Cancer Cell 30 3: Eur J Immunol 44 4: Reprogramming adult Schwann cells to stem cell-like cells by leprosy bacilli promotes dissemination of infection. Generation of mouse models for type 1 diabetes by selective depletion of pancreatic beta cells using toxin receptor-mediated cell knockout. Limited role of antibody in clearance of Streptococcus pneumoniae in a murine model of colonization.

Mol Cell 69 4: Dendritic cells induce Th2-mediated airway inflammatory responses to house dust mite via DNA-dependent protein kinase. A novel immunodeficient NOD. SCID-rd1 mouse model of retinitis pigmentosa to investigate potential therapeutics and pathogenesis of retinal degeneration. Biol Open 6 4: NK cells and gammadelta T cells mediate resistance to polyomavirus-induced tumors. Priming and effector dependence on insulin B: J Clin Invest 7: Novel antibody reagents for characterization of drug- and tumor microenvironment-induced changes in epithelial-mesenchymal transition and cancer stem cells.

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Intestinal gammadelta T cells develop in mice lacking thymus, all lymph nodes, Peyer's patches, and isolated lymphoid follicles. Strain-dependent leakiness of mice with severe combined immune deficiency. B cell-mediated antigen presentation is required for the pathogenesis of acute cardiac allograft rejection. Blockade of tumor necrosis factor in collagen-induced arthritis reveals a novel immunoregulatory pathway for Th1 and Th17 cells. Consequences of Citrobacter rodentium infection on enteroendocrine cells and the enteric nervous system in the mouse colon.

Cell Microbiol 8 4: STAT4 isoforms differentially regulate Th1 cytokine production and the severity of inflammatory bowel disease. Int Immunol 9 9: Expression of a bcl-2 transgene reduces proliferation and slows turnover of developing B lymphocytes in vivo. High susceptibility of Scid mice to colon carcinogenesis induced by azoxymethane indicates a possible caretaker role for DNA-dependent protein kinase.

Translocation of bacteria from the gastrointestinal tract in immunodeficient mice. Lab Anim 30 1: Role of gut cryptopatches in early extrathymic maturation of intestinal intraepithelial T cells. Ursodeoxycholic acid stimulates Nrf2-mediated hepatocellular transport, detoxification, and antioxidative stress systems in mice. PD-1 and LAG-3 inhibitory co-receptors act synergistically to prevent autoimmunity in mice. Biochem Biophys Res Commun 2: Exosomes from bone marrow mesenchymal stem cells contain a microRNA that promotes dormancy in metastatic breast cancer cells.

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Infect Immun 81 Dynamics and localization of early B-lymphocyte precursor cells pro-B cells in the bone marrow of scid mice. Interleukin 25 regulates type 2 cytokine-dependent immunity and limits chronic inflammation in the gastrointestinal tract. B1 B lymphocytes play a critical role in host protection against lymphatic filarial parasites. Inhibitors of tyrosine phosphatases and apoptosis reprogram lineage-marked differentiated muscle to myogenic progenitor cells. Chem Biol 18 9: Notch signaling contributes to proliferation and tumor formation of human T-cell leukemia virus type 1-associated adult T-cell leukemia.

Pro-neural miR is a glioma tumor suppressor that targets mitogenic kinases. Prkdc participates in mitochondrial genome maintenance and prevents Adriamycin-induced nephropathy in mice. Locus coeruleus neurons are resistant to dysfunction and degeneration by maintaining free ubiquitin levels although total ubiquitin levels decrease upon disruption of polyubiquitin gene Ubb.

Cancer Cell 30 6: Cell Metab 25 5: T-cell receptor transgenic response to an endogenous polymorphic autoantigen determines susceptibility to diabetes. IL-2 gene knockout affects T lymphocyte trafficking and the microglial response to regenerating facial motor neurons. J Neuroimmunol Therapeutic targeting of CC ligand 21 or CC chemokine receptor 7 abrogates pulmonary fibrosis induced by the adoptive transfer of human pulmonary fibroblasts to immunodeficient mice. Adenovirus early region 3 antiapoptotic Rhoh deficiency reduces peripheral T-cell function and attenuates allogenic transplant rejection.

Eur J Immunol 41 1: The nonobese diabetic scid mouse: Suppression of experimental colitis by intestinal mononuclear phagocytes. J Leukoc Biol 80 4: Identification of CD15 as a marker for tumor-propagating cells in a mouse model of medulloblastoma. Mol Immunol 31 Antibody-mediated protection against Cryptococcus neoformans pulmonary infection is dependent on B cells. Infect Immun 73 2: Expression of Mls determinants in mice exhibiting the severe combined immunodeficiency scid mutation or X-linked immunodeficiency xid defect.

Humanized mouse model of glucose 6-phosphate dehydrogenase deficiency for in vivo assessment of hemolytic toxicity.

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Plk4 is required for cytokinesis and maintenance of chromosomal stability. Preconditioning allows engraftment of mouse and human embryonic lung cells, enabling lung repair in mice. Nat Med 21 8: Lethal exacerbation of Pneumocystis carinii pneumonia in severe combined immunodeficiency mice after infection by pneumonia virus of mice.

Regulation of ceramide synthase-mediated crypt epithelium apoptosis by DNA damage repair enzymes. Cancer Res 70 3: Interleukin and host defense against murine Pneumocystis pneumonia. Infect Immun 76 5: Unexpected rearrangement and expression of the immunoglobulin lambda1 locus in scid mice. Methylation of insulin DNA in response to proinflammatory cytokines during the progression of autoimmune diabetes in NOD mice.

Telomerase-deficient mice exhibit bone loss owing to defects in osteoblasts and increased osteoclastogenesis by inflammatory microenvironment. J Bone Miner Res 26 7: Exhaustion of nucleus pulposus progenitor cells with ageing and degeneration of the intervertebral disc. Cyclophosphamide induces dynamic alterations in the host microenvironments resulting in a Flt3 ligand-dependent expansion of dendritic cells. Modulation of intestinal autoimmunity and IL-2 signaling by sphingosine kinase 2 independent of sphingosine 1-phosphate.

Use of a genetically engineered strain to evaluate the pathogenic potential of yeast cell and filamentous forms during Candida albicans systemic infection in immunodeficient mice.

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Infect Immun 76 1: Specific inhibition of autoimmune T cell transmigration contributes to beta cell functionality and insulin synthesis in non-obese diabetic NOD mice. Contribution of Fas to diabetes development. Infect Immun 65 8: Non-obese diabetic mice rapidly develop dramatic sympathetic neuritic dystrophy: Cutaneous inflammatory disorder in integrin alphaE CD -deficient mice. Rearrangement of antigen receptor genes is defective in mice with severe combined immune deficiency. Modulation of inflammasome-mediated pulmonary immune activation by type I IFNs protects bone marrow homeostasis during systemic responses to Pneumocystis lung infection.

Genetic interactions between ATM and the nonhomologous end-joining factors in genomic stability and development.

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Dendritic cells induce antigen-specific regulatory T cells that prevent graft versus host disease and persist in mice. Exacerbation of facial motoneuron loss after facial nerve transection in severe combined immunodeficient scid mice. An improved host for adoptive transfer of autoimmune diabetes and growth of human lymphohematopoietic cells.

Mol Immunol 44 Nitric oxide and host defense against Pneumocystis carinii infection in a mouse model. Lab Anim 31 2: Developmental malformations and intrauterine deaths in gamma-ray-irradiated scid mouse embryos. Int J Radiat Biol 73 6: Structurally distinct T cell receptor complexes on developmentally distinct T cell populations in severe combined immunodeficiency mice expressing a TCR beta transgene.

Recognition of live phosphatidylserine-labeled tumor cells by dendritic cells: Cancer Res 69 6: J Virol 71 4: Wnt signaling though beta-catenin is required for prostate lineage specification. A new immuno-, dystrophin-deficient model, the NSG-mdx 4Cv mouse, provides evidence for functional improvement following allogeneic satellite cell transplantation. Stem Cells 31 8: J Immunol 6: Imiquimod inhibits melanoma development by promoting pDC cytotoxic functions and impeding tumor vascularization.

Stem Cells 33 3: J Exp Med Characterization of human antiviral adaptive immune responses during hepatotropic virus infection in HLA-transgenic human immune system mice. Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells. Survival advantage of both human hepatocyte xenografts and genome editedhepatocytes for treatment of alpha-1 antitrypsin deficiency Mol Ther:.

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Broadly neutralizing anti-HIV-1 antibodies require Fc effector functions for in vivo activity. T-helpercell cytokines drive cancer into senescence. J Immunol Telomerase inhibition effectively targets mouse and human AML stem cells and delays relapse following chemotherapy.